作者
Bilal Rayes, Maddalena Ardissino, Eric AW Slob, Kiran Haresh Kumar Patel, Joanna Girling, Fu Siong Ng
发表日期
2023/2/1
期刊
JAMA Network Open
卷号
6
期号
2
页码范围
e230034-e230034
出版商
American Medical Association
简介
Importance
Hypertensive disorders in pregnancy (HDPs) are major causes of maternal and fetal morbidity and are observationally associated with future maternal risk of cardiovascular disease. However, observational results may be subject to residual confounding and bias.
Objective
To investigate the association of HDPs with multiple cardiovascular diseases.
Design, Setting, and Participants
A genome-wide genetic association study using mendelian randomization (MR) was performed from February 16 to March 4, 2022. Primary analysis was conducted using inverse-variance-weighted MR. Mediation analyses were performed using a multivariable MR framework. All studies included patients predominantly of European ancestry. Female-specific summary-level data from FinnGen (sixth release).
Exposures
Uncorrelated (r2<0.001) single-nucleotide variants (SNVs) were selected as instrumental variants from the …
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B Rayes, M Ardissino, EAW Slob, KHK Patel, J Girling… - JAMA Network Open, 2023