作者
Ida E Sønderby, Dennis Van der Meer, Clara Moreau, Tobias Kaufmann, G Bragi Walters, Maria Ellegaard, Abdel Abdellaoui, David Ames, Katrin Amunts, Micael Andersson, Nicola J Armstrong, Manon Bernard, Nicholas B Blackburn, John Blangero, Dorret I Boomsma, Henry Brodaty, Rachel M Brouwer, Robin Bülow, Rune Bøen, Wiepke Cahn, Vince D Calhoun, Svenja Caspers, Christopher RK Ching, Sven Cichon, Simone Ciufolini, Benedicto Crespo-Facorro, Joanne E Curran, Anders M Dale, Shareefa Dalvie, Paola Dazzan, Eco JC De Geus, Greig I De Zubicaray, Sonja MC de Zwarte, Sylvane Desrivieres, Joanne L Doherty, Gary Donohoe, Bogdan Draganski, Stefan Ehrlich, Else Eising, Thomas Espeseth, Kim Fejgin, Simon E Fisher, Tormod Fladby, Oleksandr Frei, Vincent Frouin, Masaki Fukunaga, Thomas Gareau, Tian Ge, David C Glahn, Hans J Grabe, Nynke A Groenewold, Omar Gustafsson, Jan Haavik, Asta K Haberg, Jeremy Hall, Ryota Hashimoto, Jayne Y Hehir-Kwa, Derrek P Hibar, Manon HJ Hillegers, Per Hoffmann, Laurena Holleran, Avram J Holmes, Georg Homuth, Jouke-Jan Hottenga, Hilleke E Hulshoff Pol, Masashi Ikeda, Neda Jahanshad, Christiane Jockwitz, Stefan Johansson, Erik G Joensson, Niklas R Jørgensen, Masataka Kikuchi, Emma EM Knowles, Kuldeep Kumar, Stephanie Le Hellard, Costin Leu, David EJ Linden, Jingyu Liu, Arvid Lundervold, Astri Johansen Lundervold, Anne M Maillard, Nicholas G Martin, Sandra Martin-Brevet, Karen A Mather, Samuel R Mathias, Katie L McMahon, Allan F McRae, Sarah E Medland, Andreas Meyer-Lindenberg, Torgeir Moberget, Claudia Modenato, Jennifer Monereo Sanchez, Derek W Morris, Thomas W Muehleisen, Robin M Murray, Jacob Nielsen, Jan E Nordvik, Lars Nyberg, Loes M Olde Loohuis, Roel A Ophoff, Michael J Owen, Tomas Paus, Zdenka Pausova, Juan M Peralta, G Bruce Pike, Carlos Prieto, Erin B Quinlan, Celine S Reinbold, Tiago Reis Marques, James JH Rucker, Perminder S Sachdev, Sigrid B Sando, Peter R Schofield, Andrew J Schork, Gunter Schumann, Jean Shin, Elena Shumskaya, Ana I Silva, Sanjay M Sisodiya, Vidar M Steen, Dan J Stein, Lachlan T Strike, Ikuo K Suzuki, Christian K Tamnes, Alexander Teumer, Anbupalam Thalamuthu, Diana Tordesillas-Gutierrez, Anne Uhlmann, Magnus O Ulfarsson, Dennis van ‘t Ent, Marianne BM van den Bree, Pierre Vanderhaeghen, Evangelos Vassos, Wei Wen, Katharina Wittfeld, Margaret J Wright, Ingrid Agartz, Srdjan Djurovic, Lars T Westlye, Hreinn Stefansson, Kari Stefansson, Sebastien Jacquemont, Paul M Thompson, Ole A Andreassen, ENIGMA-CNV working group van der Meer Dennis 1 4 de Geus Eco JC 12 22 23 de Zubicaray Greig I. 41 de Zwarte Sonja MC 26 Le Hellard Stephanie 90 91 van ‘t Ent Dennis 12 22 van den Bree Marianne BM 43 71
发表日期
2021/3/22
期刊
Translational psychiatry
卷号
11
期号
1
页码范围
182
出版商
Nature Publishing Group UK
简介
Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers display a high prevalence of micro- and macrocephaly in deletion and duplication carriers, respectively. The underlying brain structural diversity remains largely unknown. We systematically called CNVs in 38 cohorts from the large-scale ENIGMA-CNV collaboration and the UK Biobank and identified 28 1q21.1 distal deletion and 22 duplication carriers and 37,088 non-carriers (48% male) derived from 15 distinct magnetic resonance imaging scanner sites. With standardized methods, we compared subcortical and cortical brain measures (all) and cognitive performance (UK Biobank only) between carrier groups also testing for mediation of brain structure on cognition. We identified positive …
学术搜索中的文章
1q21. 1 distal copy number variants are associated with cerebral and cognitive alterations in humans
IE Sønderby, D Van der Meer, C Moreau, T Kaufmann… - Translational psychiatry, 2021