作者
James L Alexander, Benjamin H Mullish, Nathan P Danckert, Zhigang Liu, Marton L Olbei, Aamir Saifuddin, Melissa Torkizadeh, Hajir Ibraheim, Jesús Miguéns Blanco, Lauren A Roberts, Claire M Bewshea, Rachel Nice, Simeng Lin, Hemanth Prabhudev, Caroline Sands, Verena Horneffer-van der Sluis, Matthew Lewis, Shaji Sebastian, Charlie W Lees, Julian P Teare, Ailsa Hart, James R Goodhand, Nicholas A Kennedy, Tamas Korcsmaros, Julian R Marchesi, Tariq Ahmad, Nick Powell
发表日期
2023/2/1
期刊
EBioMedicine
卷号
88
出版商
Elsevier
简介
Background
Patients with inflammatory bowel disease (IBD) treated with anti-TNF therapy exhibit attenuated humoral immune responses to vaccination against SARS-CoV-2. The gut microbiota and its functional metabolic output, which are perturbed in IBD, play an important role in shaping host immune responses. We explored whether the gut microbiota and metabolome could explain variation in anti-SARS-CoV-2 vaccination responses in immunosuppressed IBD patients.
Methods
Faecal and serum samples were prospectively collected from infliximab-treated patients with IBD in the CLARITY-IBD study undergoing vaccination against SARS-CoV-2. Antibody responses were measured following two doses of either ChAdOx1 nCoV-19 or BNT162b2 vaccine. Patients were classified as having responses above or below the geometric mean of the wider CLARITY-IBD cohort. 16S rRNA gene amplicon sequencing …
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JL Alexander, BH Mullish, NP Danckert, Z Liu, ML Olbei… - EBioMedicine, 2023