作者
Ane Fernandez Salinas, Eva Piano Mortari, Sara Terreri, Concetta Quintarelli, Federica Pulvirenti, Stefano Di Cecca, Marika Guercio, Cinzia Milito, Livia Bonanni, Stefania Auria, Laura Romaggioli, Giuseppina Cusano, Christian Albano, Salvatore Zaffina, Carlo Federico Perno, Giuseppe Spadaro, Franco Locatelli, Rita Carsetti, Isabella Quinti
发表日期
2021/11
期刊
Journal of clinical immunology
卷号
41
页码范围
1709-1722
出版商
Springer US
简介
Background
Data on immune responses to SARS-CoV-2 in patients with Primary Antibody Deficiencies (PAD) are limited to infected patients and to heterogeneous cohorts after immunization.
Methods
Forty-one patients with Common Variable Immune Deficiencies (CVID), six patients with X-linked Agammaglobulinemia (XLA), and 28 healthy age-matched controls (HD) were analyzed for anti-Spike and anti-receptor binding domain (RBD) antibody production, generation of Spike-specific memory B-cells, and Spike-specific T-cells before vaccination and one week after the second dose of BNT162b2 vaccine.
Results
The vaccine induced Spike-specific IgG and IgA antibody responses in all HD and in 20% of SARS-CoV-2 naive CVID patients. Anti-Spike IgG were detectable before vaccination in 4 out 7 CVID previously …
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AF Salinas, EP Mortari, S Terreri, C Quintarelli… - Journal of clinical immunology, 2021