作者
Yi Han, Kang Shi, Shi-Jie Zhou, Da-Ping Yu, Zhi-Dong Liu
发表日期
2016/8/16
来源
OncoTargets and therapy
页码范围
5081-5090
出版商
Taylor & Francis
简介
The hMLH1 gene plays an essential role in DNA repair. Methylation of the hMLH1 gene is common in many types of cancer and can lead to the loss of hMLH1 expression. However, the association and clinicopathological significance between hMLH1 promoter hypermethylation and non-small-cell lung cancer (NSCLC) is elusive. Here, we investigated the correlation of hMLH1 promoter hypermethylation and NSCLC using 13 studies by comprising 1,056 lung cancer patients via a meta-analysis. We observed that 1) loss of hMLH1 protein expression was significantly associated with its promoter hypermethylation, 2) hMLH1 gene inactivation through hypermethylation contributed to the tumorigenesis of NSCLC, which could be a decisive factor for the pathogenesis of NSCLC due to its high occurrence in NSCLC tissues compared to normal lung tissues, 3) a correlation exists between histologic subtypes/disease …
学术搜索中的文章
Y Han, K Shi, SJ Zhou, DP Yu, ZD Liu - OncoTargets and therapy, 2016