作者
Jung Yun Chang, Yu-Kyoung Oh, Hak Soo Kong, Eun Jung Kim, Dong Deuk Jang, Ki Taek Nam, Chong-Kook Kim
发表日期
2002/7/18
期刊
Journal of controlled release
卷号
82
期号
1
页码范围
39-50
出版商
Elsevier
简介
To develop more effective treatment for vaginal candidasis, clotrimazole (CT) was formulated in mucoadhesive thermosensitive gels (MTG). Several MTG formulations composed of poloxamers (P) 407, 188, and polycarbophil (PC) were prepared. P188 and PC increased the mucoadhesiveness but reduced the syringebility of liquid forms of the gels. Based on the balance between the mucoadhesiveness and syringebility, MTG composed of P407/P188/PC (15/15/0.2 or 15/20/0.2) were further studied. Of the two MTG, the formulation with 15% of P188 gelled at higher temperature and revealed lower elastic modulus. In vitro, sustained release of CT from MTG was observed. In vivo antifungal activity of CT, tested against Candida albicans vaginitis in female rats, was significantly prolonged after vaginal delivery using MTG. At 10 days post-dose, the c.f.u. of C. albicans was more than 104-fold decreased in MTG-treated …
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JY Chang, YK Oh, HS Kong, EJ Kim, DD Jang, KT Nam… - Journal of controlled release, 2002