作者
Jung Yun Chang, Yu-Kyoung Oh, Han-gon Choi, Yang Bae Kim, Chong-Kook Kim
发表日期
2002/7/8
期刊
International journal of pharmaceutics
卷号
241
期号
1
页码范围
155-163
出版商
Elsevier
简介
The timely gelation and retention of in situ-gelling vaginal formulations would be fundamental to improve the efficacy of drugs. In this study, various rheological properties of clotrimazole gels were evaluated for predicting their performance in vagina. Two kinds of thermosensitive and mucoadhesive formulations were composed of poloxamer 407 (P407, 15%), polycarbophil (0.2%), and different amounts of P188 (15 vs. 20%). Both formulations were Newtonian at 20°C but non-Newtonian at 37°C. Although both liquid formulations gelled below the vaginal temperature, they differed in gelation time and viscoelastic properties in the presence of vaginal fluid simulant. At body temperature, the formulation with 20% of P188 gelled within 35 s but it took two times longer for the other one gelled. Upon dilution with simulated vaginal fluid, the formulation with 20% of P188 retained the rheology of a gel, but the other one lost …
引用总数
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JY Chang, YK Oh, H Choi, YB Kim, CK Kim - International journal of pharmaceutics, 2002