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The development of intracellular ice in the bodies of cold-blooded living organisms may cause them to die. These species yield antifreeze proteins (AFPs) to live in subzero temperature environments. Additionally, AFPs are implemented in biotechnological, industrial, agricultural, and medical fields. Machine learning-based predictors were presented for AFP identification. However, more accurate predictors are still highly desirable for boosting the AFP prediction. This work presents a novel approach, named AFP-SPTS, for the correct prediction of AFPs. We explored the discriminative features with four schemes, namely, dipeptide deviation from the expected mean (DDE), reduced amino acid alphabet (RAAA), grouped dipeptide composition (GDPC), and a novel representative method, called pseudo-position-specific scoring matrix tri-slicing (PseTS-PSSM). Considering the advantages of ensemble learning strategy …