作者
Qiufang Chen, Jun Zhou, Zhe Chen, Qing Luo, Jian Xu, Guanbin Song
发表日期
2019/8/9
期刊
ACS applied materials & interfaces
卷号
11
期号
34
页码范围
30551-30565
出版商
American Chemical Society
简介
Amplifying intracellular oxidative stress effectively destroys cancer cells. In addition, iron-mediated Fenton reaction converts endogenous H2O2 to produce hypertoxic hydroxyl radical (•OH), resulting in irreversible oxidative damage to combat tumor cells. This method is known as chemodynamic therapy (CDT). Overexpressed glutathione (GSH) in tumor cells efficiently scavenges •OH, significantly reducing the curative effects of CDT. To overcome this challenge and enhance intracellular oxidative stress, iron oxide nanocarriers loaded with β-lapachone (Lapa) drugs (Fe3O4-HSA@Lapa) were constructed and had both Fenton-like agents and GSH depletion properties to amplify intracellular oxidative stress. Release of Lapa selectively increases tumor site-specific generation of H2O2 via NAD(P)H: quinone oxidoreductase 1 (NQO1) catalysis. Subsequently, the iron ions released from the ionization of Fe3O4 in the …
学术搜索中的文章
Q Chen, J Zhou, Z Chen, Q Luo, J Xu, G Song - ACS applied materials & interfaces, 2019