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To determine the acceptability of childhood HPV vaccination and examine demographic, cultural, and psychosocial predictors of vaccine acceptance.

School-based survey.

Questionnaires sent to 1205 mothers of 8–14-year-old girls. Responses from 684 were included in the analyses.

Ten schools (seven primary, three secondary) in four areas of England.

Seventy-five percent of mothers would accept the vaccine for their daughter. Vaccine acceptance was higher in mothers who had experience of cancer in the family (OR=1.61, CI: 1.14–2.29), had older daughters (OR=1.15, CI: 1.04–1.27), perceived approval from husband/partner (OR=14.51, CI: 6.15–34.25) and believed vaccine acceptance would be more normative (OR=1.78, CI: 1.59–2.01). Having concerns about too many vaccinations (OR=0.22, CI: 0.15–0.31) or vaccine side effects (OR=0.37, CI: 0 …