作者
A Skytthe, Silvana Valensin, B Jeune, Elisa Cevenini, Frédéric Balard, M Beekman, V Bezrukov, H Blanche, L Bolund, K Broczek, C Carru, K Christensen, L Christiansen, JC Collerton, R Cotichini, AJM de Craen, Serena Dato, K Davies, G De Benedictis, L Deiana, F Flachsbart, J Gampe, C Gilbault, Efstathios S Gonos, E Haimes, A Hervonen, MA Hurme, D Janiszewska, M Jylhä, TBL Kirkwood, Peter Kristensen, P Laiho, A Leon, A Marchisio, R Masciulli, A Nebel, Giuseppe Passarino, G Pelicci, Leena Peltonen, Markus Perola, M Poulain, IM Rea, J Remacle, JM Robine, S Schreiber, Maria Scurti, Federica Sevini, E Sikora, A Skouteri, PE Slagboom, L Spazzafumo, MA Stazi, V Toccaceli, O Toussaint, Outi Törnwall, JW Vaupel, Konstantinos Voutetakis, Claudio Franceschi
发表日期
2011/11/1
期刊
Experimental gerontology
卷号
46
期号
11
页码范围
934-945
出版商
Pergamon
简介
In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identified and included in the project. In addition, 2548 younger control persons aged 50–75years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control …
学术搜索中的文章
Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project
A Skytthe, S Valensin, B Jeune, E Cevenini, F Balard… - Experimental gerontology, 2011