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Most of the ayurvedic medicines are in the form of powder and they may have some kind of unacceptable or bitter taste and have problem of patient compliance. Medicines in powder form have problem of administration of accurate dose with ease. Furthermore it needs water or honey for administration and chances of spoilage and waste are more. Formulation of Oro-dispersible tablets which rapidly disintegrate in mouth will be the best remedy for efficient use of ayurvedic powders. The aim of this study was to formulate oro-dispersible tablets of ayurvedic polyherbal powder Sitopaladi and Talisadi using various excipients like super-disintegrants and sweeteners and compare the efficacy in vivo using rats. The cough suppressing activities of powder and tablets was evaluated by counting bouts of cough in control group and treated group rats with powders and ODT. Codeine was taken as standard anti-tussive drug …