查看文章

Box Behnken Design is a factorial statistical approach that helps to overcome limitations associated with time-consuming full factorial experimental design. This study used the Box Behnken design and Design of Experiments (DoE) to develop the nebulized antiviral Camostat Mesylate loaded pegylated nanoliposomal suspension product with the target profile specifications of particle size <250nm, polydispersity index (PDI) between 0.1-0.3, and zeta potential (ZP) of 0±5mV, % entrapment efficiency (%EE) between 40%w/v to 70% w/v and % drug loading between 20%w/w to 50%w/w. Box Behnken design with a robust standard least squares model was employed to develop the pharma product. Camostat Mesylate loaded pegylated nanoliposomal suspension was developed using the scalable ethanol injection method. The three independent factors at three levels were concentrations of the lipids employed to …