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Decentralized Finance (DeFi) stands for a new paradigm that aims to disrupt established financial services. It offers services in the form of smart contracts, which are executable software programs deployed on top of blockchains such as Ethereum. Despite being a relatively recent development, we can already observe rapid growth in DeFi protocols enabling the lending of cryptoassets, exchanging them for other cryptoassets without intermediaries, or betting on future price developments.[...] DeFi protocols are seemingly independent financial services offered to users. However, as shown in our recent study (Kitzler et al. 2022), a closer look beneath the surface reveals a highly intertwined and deeply nested structure of smart contracts [...]. We present, for the first time, the Smart Contract Dependency Network as an approach for modeling and measuring systemic risks in the Decentralized Finance ecosystem and quantify the systemic risk of single smart contracts for the overall DeFi ecosystem.