作者
Nikos Papadimitriou, Niki Dimou, Konstantinos K Tsilidis, Barbara Banbury, Richard M Martin, Sarah J Lewis, Nabila Kazmi, Timothy M Robinson, Demetrius Albanes, Krasimira Aleksandrova, Sonja I Berndt, D Timothy Bishop, Hermann Brenner, Daniel D Buchanan, Bas Bueno-de-Mesquita, Peter T Campbell, Sergi Castellví-Bel, Andrew T Chan, Jenny Chang-Claude, Merete Ellingjord-Dale, Jane C Figueiredo, Steven J Gallinger, Graham G Giles, Edward Giovannucci, Stephen B Gruber, Andrea Gsur, Jochen Hampe, Heather Hampel, Sophia Harlid, Tabitha A Harrison, Michael Hoffmeister, John L Hopper, Li Hsu, José María Huerta, Jeroen R Huyghe, Mark A Jenkins, Temitope O Keku, Tilman Kühn, Carlo La Vecchia, Loic Le Marchand, Christopher I Li, Li Li, Annika Lindblom, Noralane M Lindor, Brigid Lynch, Sanford D Markowitz, Giovanna Masala, Anne M May, Roger Milne, Evelyn Monninkhof, Lorena Moreno, Victor Moreno, Polly A Newcomb, Kenneth Offit, Vittorio Perduca, Paul DP Pharoah, Elizabeth A Platz, John D Potter, Gad Rennert, Elio Riboli, Maria-Jose Sánchez, Stephanie L Schmit, Robert E Schoen, Gianluca Severi, Sabina Sieri, Martha L Slattery, Mingyang Song, Catherine M Tangen, Stephen N Thibodeau, Ruth C Travis, Antonia Trichopoulou, Cornelia M Ulrich, Franzel JB van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Ulrike Peters, Marc J Gunter, Neil Murphy
发表日期
2020/1/30
期刊
Nature communications
卷号
11
期号
1
页码范围
1-10
出版商
Nature Publishing Group
简介
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an …
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N Papadimitriou, N Dimou, KK Tsilidis, B Banbury… - Nature communications, 2020