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Purpose

To investigate the expression of αA-and αB-crystallin and heat shock protein 70 (Hsp 70) during curcumin treatment of selenium-induced cataractogenesis in Wistar rat pups.

Methods

Group I Wistar rat pups received only saline and served as the control. Group II Wistar rat pups were intraperitoneally injected with selenium (15 µM/kg bodyweight) to induce cataract. Group III Wistar rat pups also underwent selenium-induced cataract but were cotreated with 75 mg/kg body weight of curcumin (single oral dose). Group IV Wistar rat pups with selenium-induced cataract were post-treated with curcumin at the group III dosage 24 h after selenium administration. Group V Wistar rat pups with selenium-induced cataract were pretreated with curcumin at the group III dosage 24 h before selenium administration.

Results

This study found higher levels of αA-and αB-crystallin and Hsp 70 in lenses injected with selenium …