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The aim of the study was to find out the phytochemical evaluation, cytotoxic, anthelmintic & thrombolytic activity from the leaves of Mikania micrantha. Mikania micrantha (Asteraceae), commonly known as mile-a-minute weed is an extremely fast-growing, perennial creeping weed. To study for Phytochemical evaluation was determined through qualitative analysis. The cytotoxic activity was determined by using brine shrimp lethality bioassay. Anthelmintic activity by the study of paralysis and death time and was compared with albendazole as the reference standard, Thrombolytic activity by clot disruption. Phytochemical evaluation indicates the presence of chemical constituents including flavonoids, steroids, saponins & some amount of alkaloids & glycosides. In cytotoxicity assay, the LC50 values of the sample were (7.51) µl/ml where the LC50 values of the standard potassium dichromate were (124.13) µl/ml as a positive control. In the anthelmintic assay, there is no paralyzed and death worm through ethanol extract whereas standard albendazole showed paralyzed & dead worm. The extract shows (86.87)% for 200mg and (84.15)% for 100mg clot lytic whereas standard streptokinase shows (87.33)% for 30,000 IU and (82.11)% for 15,000 IU clot lytic activity in thrombolytic activity assay. This study shows that the ethanol extract of Mikania micrantha has some bioactivity but further compound isolation is necessary to confirm the activities of individual compounds.