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In this paper, session key exchange and authentication technique executing in parallel fashion using the fine tuning of Two Tier Neural Network in wireless communication has been proposed for secured information transmission. E-Health online transmission of any medical information needs cryptographic implementations. Any medical information related to the patients which need to be shared secretly between different authorized parties. This proposed technique can be merged with any digitized cardiological-based Expert System with patients’ data preservation. Ischemic Heart Disease (IHD) is a set of cardiovascular problems with decreased blood flow rate. It is mainly caused due to narrowing of coronary arteries due to plaque accumulation in the channel. ECG signal diagnosing IHD is being digitized for secured transmission purpose. In this proposed technique identical Two Tier Neural Network is …