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Scholarly investigations into male and female sexuality over the life course have long occupied two separate “camps”: One focused on the biological aspects of sexuality and one focused on the sociocultural/political aspects. This bifurcated approach has been particularly ill suited for the study of sexual desire, a topic that has been generally undertheorized by sex researchers. A modern reappraisal of gender and sexual desire is proposed that takes into coordinated account both the biological and sociocultural/political factors that produce and shape subjective sexual desires over the life course. The specific relevance of this approach for three particular topic areas, adolescent sexual maturation, same-sex sexuality, and sexual dysfunction, is addressed. Methodological approaches to the study of gender and sexuality capable of investigating how cultural and biological factors intersect to shape the subjective …