作者
Hanga Galfalvy, Fatemeh Haghighi, Colin Hodgkinson, David Goldman, Maria A Oquendo, Ainsley Burke, Yung‐yu Huang, Ina Giegling, Dan Rujescu, Alexandre Bureau, Gustavo Turecki, J John Mann
发表日期
2015/10
期刊
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
卷号
168
期号
7
页码范围
557-563
简介
Genome wide array studies have reported limited success in identifying genetic markers conferring risk for suicidal behavior (SB). This may be attributable to study designs with primary outcome other than SB. We performed a GWAS on suicides and cases with a history of nonfatal suicide attempts compared with psychiatric controls and healthy volunteers. A consortium of USA, Canadian and German teams assembled two groups of cases (suicide attempters and suicides, N = 577) and non‐attempter psychiatric and healthy controls (N = 1,233). Logistic regression was used to test genotype‐suicidal behavior association. The test was repeated separating suicide attempt and completed suicide as outcomes. No SNP reached genome‐wide significance, but several SNPs within STK3, ADAMTS14, PSME2, and TBX20 genes reached P < 1 × 10−5. The top SNPs for the suicide attempt analysis included two …
引用总数
201620172018201920202021202220232024816151616161094
学术搜索中的文章
H Galfalvy, F Haghighi, C Hodgkinson, D Goldman… - American Journal of Medical Genetics Part B …, 2015