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This paper analyses the link between technological regimes and persistence in innovation at the firm level. It reviews the literature on persistence of innovation, measurement issues and technological regimes. It weighs up the advantages and disadvantages of using Community Innovation Survey (CIS) data in this debate. Technological regimes and innovation persistence are analysed with a balanced panel of around 4,000 firms that responded to the latest three waves of the UK version of the CIS. Key explanatory variables include measures of appropriability, cumulativeness, technological opportunity and closeness to the science base. We find that certain links between type of industry and characteristics of technological regime are more appropriate for analysis using CIS data, whereas others remain problematic.