作者
Ellie Paige, Marc Clément, Fabien Lareyre, Michael Sweeting, Juliette Raffort, Céline Grenier, Alison Finigan, James Harrison, James E Peters, Benjamin B Sun, Adam S Butterworth, Seamus C Harrison, Matthew J Bown, Jes S Lindholt, Stephen A Badger, Iftikhar J Kullo, Janet Powell, Paul E Norman, D Julian A Scott, Marc A Bailey, Stefan Rose-John, John Danesh, Daniel F Freitag, Dirk S Paul, Ziad Mallat
发表日期
2019/2
期刊
Circulation: Genomic and Precision Medicine
卷号
12
期号
2
页码范围
e002413
出版商
Lippincott Williams & Wilkins
简介
Background
The Asp358Ala variant (rs2228145; A>C) in the IL (interleukin)-6 receptor (IL6R) gene has been implicated in the development of abdominal aortic aneurysms (AAAs), but its effect on AAA growth over time is not known. We aimed to investigate the clinical association between the IL6R-Asp358Ala variant and AAA growth and to assess the effect of blocking the IL-6 signaling pathway in mouse models of aortic aneurysm rupture or dissection.
Methods
Using data from 2863 participants with AAA from 9 prospective cohorts, age- and sex-adjusted mixed-effects linear regression models were used to estimate the association between the IL6R-Asp358Ala variant and annual change in AAA diameter (mm/y). In a series of complementary randomized trials in mice, the effect of blocking the IL-6 signaling pathways was assessed on plasma biomarkers, systolic blood pressure, aneurysm diameter, and time to …
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E Paige, M Clément, F Lareyre, M Sweeting, J Raffort… - Circulation: Genomic and Precision Medicine, 2019
E Paige, M Clément, F Lareyre, M Sweeting, J Raffort… - 2019