作者
S Bhattacharya, K Harrild, J Mollison, S Wordsworth, C Tay, A Harrold, D McQueen, H Lyall, L Johnston, J Burrage, S Grossett, H Walton, J Lynch, A Johnstone, S Kini, A Raja, A Templeton
发表日期
2008/8/7
期刊
Bmj
卷号
337
出版商
British Medical Journal Publishing Group
简介
Objective To compare the effectiveness of clomifene citrate and unstimulated intrauterine insemination with expectant management for the treatment of unexplained infertility.
Design Three arm parallel group, pragmatic randomised controlled trial.
Setting Four teaching hospitals and a district general hospital in Scotland.
Participants Couples with infertility for over two years, confirmed ovulation, patent fallopian tubes, and motile sperm.
Intervention Expectant management, oral clomifene citrate, and unstimulated intrauterine insemination.
Main outcome measures The primary outcome was live birth. Secondary outcome measures included clinical pregnancy, multiple pregnancy, miscarriage, and acceptability.
Results 580 women were randomised to expectant management (n=193), oral clomifene citrate (n=194), or unstimulated intrauterine insemination (n=193) for six months. The three randomised groups were …
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