作者
Brian O'Sullivan, Shao Hui Huang, Lillian L Siu, John Waldron, Helen Zhao, Bayardo Perez-Ordonez, Ilan Weinreb, John Kim, Jolie Ringash, Andrew Bayley, Laura A Dawson, Andrew Hope, John Cho, Jonathan Irish, Ralph Gilbert, Patrick Gullane, Angela Hui, Fei-Fei Liu, Eric Chen, Wei Xu
发表日期
2013/2/10
期刊
Journal of clinical oncology
卷号
31
期号
5
页码范围
543-550
出版商
American Society of Clinical Oncology
简介
Purpose
To define human papillomavirus (HPV) –positive oropharyngeal cancers (OPC) suitable for treatment deintensification according to low risk of distant metastasis (DM).
Patients and Methods
OPC treated with radiotherapy (RT) or chemoradiotherapy (CRT) from 2001 to 2009 were included. Outcomes were compared for HPV-positive versus HPV-negative patients. Univariate and multivariate analyses identified outcome predictors. Recursive partitioning analysis (RPA) stratified the DM risk.
Results
HPV status was ascertained in 505 (56%) of 899 consecutive OPCs. Median follow-up was 3.9 years. HPV-positive patients (n = 382), compared with HPV-negative patients (n = 123), had higher local (94% v 80%, respectively, at 3 years; P < .01) and regional control (95% v 82%, respectively; P < .01) but similar distant control (DC; 90% v 86%, respectively; P = .53). Multivariate analysis identified that HPV …
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B O'Sullivan, SH Huang, LL Siu, J Waldron, H Zhao… - Journal of clinical oncology, 2013