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PowerPoint is a dominant communication tool in business and education. It allows for creating professional-looking presentations easily, but without understanding its constraining qualities it can be used inappropriately. Therefore we conducted a systematic literature review structuring the literature on PowerPoint in three chronological phases (Early Criticism, Heated Debate, and Scientific Take-Off) and identifying 18 constraining qualities classified into three categories: cognitive, emotional, and social. This article provides implications for educators’ and practitioners’ use (and nonuse) of PowerPoint through synthesis and description of such constraining qualities. Directions for future research are developed by identifying theoretical gaps in literature on PowerPoint.