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This study presents a model to characterize changes in network traffic flows as a result of implementing connected and autonomous vehicle (CAV) technology based on traffic network and built-environment characteristics. To develop such a model, first, the POLARIS agent-based modeling platform is used to predict changes in average daily traffic (ADT) under CAV scenario in the road network of Chicago metropolitan area as the dependent variable of the model. Second, a comprehensive set of variables and indicators representing network characteristics and urban structure patterns are generated. Finally, three machine learning techniques, namely, K-Nearest neighbors, Random Forest, and eXtreme Gradient Boosting, are used to characterize changes in ADT based on network characteristics under a CAV scenario. The estimated models are validated and are found to yield acceptable performance. In addition …