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The UK’s industrial strategy, with local variants, aims to support manufacturing in ‘traditional industrial regions’ (TIRs). Using novel data for advanced manufacturing (AM) industries over several decades, we examine long-term changes in their geography by regions and local authority districts. These industries have shifted away from large urban regions, and local authority districts in TIRs have lost ground relative to those in other regions, although there are variations between industries. Foreign direct investment has tended to locate in non-TIR locations. AM industries have not shifted decisively towards research-intensive regions. We consider the implications for policy initiatives seeking to spark clusters around innovation districts.