作者
Stefano Rizza, Ranganath Muniyappa, Micaela Iantorno, Jeong-a Kim, Hui Chen, Philomena Pullikotil, Nicoletta Senese, Manfredi Tesauro, Davide Lauro, Carmine Cardillo, Michael J Quon
发表日期
2011/5/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
96
期号
5
页码范围
E782-E792
出版商
Oxford University Press
简介
Context
Hesperidin, a citrus flavonoid, and its metabolite hesperetin may have vascular actions relevant to their health benefits. Molecular and physiological mechanisms of hesperetin actions are unknown.
Objective
We tested whether hesperetin stimulates production of nitric oxide (NO) from vascular endothelium and evaluated endothelial function in subjects with metabolic syndrome on oral hesperidin therapy.
Design, Setting, and Interventions
Cellular mechanisms of action of hesperetin were evaluated in bovine aortic endothelial cells (BAEC) in primary culture. A randomized, placebo-controlled, double-blind, crossover trial examined whether oral hesperidin administration (500 mg once daily for 3 wk) improves endothelial function in individuals with metabolic syndrome (n = 24).
Main Outcome Measure
We measured the difference in …
学术搜索中的文章
S Rizza, R Muniyappa, M Iantorno, J Kim, H Chen… - The Journal of Clinical Endocrinology & Metabolism, 2011