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Diabetic patients are at the risk of developing different eye diseases i.e., diabetic retinopathy (DR), diabetic macular edema (DME) and glaucoma. DR is an eye disease that harms the retina and DME is developed by the accumulation of fluid in the macula, while glaucoma damages the optic disk and causes vision loss in advanced stages. However, due to slow progression, the disease shows few signs in early stages, hence making disease detection a difficult task. Therefore, a fully automated system is required to support the detection and screening process at early stages. In this paper, an automated disease localization and segmentation approach based on Fast Region-based Convolutional Neural Network (FRCNN) algorithm with fuzzy k-means (FKM) clustering is presented. The FRCNN is an object detection approach that requires the bounding-box annotations to work; however, datasets do not provide them, therefore, we have generated these annotations through ground-truths. Afterward, FRCNN is trained over the annotated images for localization that are then segmented-out through FKM clustering. The segmented regions are then compared against the ground-truths through intersection-over-union operations. For performance evaluation, we used the Diaretdb1, MESSIDOR, ORIGA, DR-HAGIS, and HRF datasets. A rigorous comparison against the latest methods confirms the efficacy of the approach in terms of both disease detection and segmentation.