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Feature selection plays a pivotal role in handling today’s high-dimensional databases by keeping only the most valuable features, leading to less computation, improved performance, and higher transparency in decision-making processes. Despite the considerable advances in combinatorial optimization, this data-preprocessing step is computationally NP-hard and continues to pose critical challenges, particularly for very high-dimensional (VHD) databases. Here, we propose integer coding and fuzzy granulation (FG) as an integral part of evolutionary wrapper-based feature selection. Based on this integer coding, we further propose crossover and mutation operators that employ set operations such as ‘union,’ ‘intersection,’ and ‘complement’ for higher transparency in their evolutionary explorative and exploitative search processes. In addition to its common use as a surrogate technique to avoid unnecessary …