作者
Siew-Wai Fong, Nicholas Kim-Wah Yeo, Yi-Hao Chan, Yun Shan Goh, Siti Naqiah Amrun, Nicholas Ang, Menaka Priyadharsani Rajapakse, Josephine Lum, Shihui Foo, Cheryl Yi-Pin Lee, Guillaume Carissimo, Rhonda Sin-Ling Chee, Anthony Torres-Ruesta, Matthew Zirui Tay, Zi Wei Chang, Chek Meng Poh, Barnaby Edward Young, Paul A Tambyah, Shirin Kalimuddin, Yee-Sin Leo, David C Lye, Bernett Lee, Subhra Biswas, Shanshan Wu Howland, Laurent Renia, Lisa FP Ng
发表日期
2022/2/1
期刊
Journal of Clinical Immunology
页码范围
1-16
出版商
Springer US
简介
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that have become dominant as the pandemic progresses bear the ORF8 mutation together with multiple spike mutations. A 382-nucleotide deletion (Δ382) in the ORF7b and ORF8 regions has been associated with milder disease phenotype and less systemic inflammation in COVID-19 patients. However, its impact on host immunity against SARS-CoV-2 remains undefined. Here, RNA-sequencing was performed to elucidate whole blood transcriptomic profiles and identify contrasting immune signatures between patients infected with either wildtype or Δ382 SARS-CoV-2 variant. Interestingly, the immune landscape of Δ382 SARS-CoV-2 infected patients featured an increased adaptive immune response, evidenced by enrichment of genes related to T cell functionality, a more robust SARS-CoV-2-specific T cell …
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