作者
Jian-Wu Xie, Lei Yue, Wei Chen, Wei Du, Jin Zhu, Jin-Gen Deng, Ying-Chun Chen
发表日期
2007/2/1
期刊
Organic letters
卷号
9
期号
3
页码范围
413-415
出版商
American Chemical Society
简介
The highly enantioselective Michael addition of 1,3-cyclic dicarbonyl compounds to α,β-unsaturated ketones was reported to be catalyzed by an organic primary amine derived from quinine. A chiral anticoagulant drug, (S)-warfarin, was directly prepared in 96% ee, and other related important adducts were also obtained in excellent enantioselectivity (89−99% ee).
引用总数
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JW Xie, L Yue, W Chen, W Du, J Zhu, JG Deng… - Organic letters, 2007