作者
Lani Prideaux, Seungha Kang, Josef Wagner, Michael Buckley, Jackie E Mahar, Peter De Cruz, Zhonghui Wen, Liping Chen, Bing Xia, Daniel R Van Langenberg, Trevor Lockett, Siew C Ng, Joseph JY Sung, Paul Desmond, Chris McSweeney, Mark Morrison, Carl D Kirkwood, Michael A Kamm
发表日期
2013/12/1
期刊
Inflammatory bowel diseases
卷号
19
期号
13
页码范围
2906-2918
出版商
Oxford University Press
简介
Background
The gut microbiota is central to health and disorders such as inflammatory bowel disease. Differences in microbiota related to geography and ethnicity may hold the key to recent changes in the incidence of microbiota-related disorders.
Methods
Gut mucosal microbiota was analyzed in 190 samples from 87 Caucasian and Chinese subjects, from Australia and Hong Kong, comprising 22 patients with Crohn's disease, 30 patients with ulcerative colitis, 29 healthy controls, and 6 healthy relatives of patients with Crohn's disease. Bacterial 16S rRNA microarray and 454 pyrosequencing were performed.
Results
The microbiota was diverse in health, regardless of ethnicity or geography (operational taxonomic unit number and Shannon diversity index). Ethnicity and geography, however, did affect microbial composition. Crohn's disease resulted in …
学术搜索中的文章
L Prideaux, S Kang, J Wagner, M Buckley, JE Mahar… - Inflammatory bowel diseases, 2013