作者
Jigang Wang, Xiaojie Qiu, Yuhua Li, Youping Deng, Tieliu Shi
发表日期
2011/12
期刊
BMC Systems Biology
卷号
5
页码范围
1-11
出版商
BioMed Central
简介
Background
To understand transcriptional regulatory networks (TRNs), especially the coordinated dynamic regulation between transcription factors (TFs) and their corresponding target genes during development, computational approaches would represent significant advances in the genome-wide expression analysis. The major challenges for the experiments include monitoring the time-specific TFs' activities and identifying the dynamic regulatory relationships between TFs and their target genes, both of which are currently not yet available at the large scale. However, various methods have been proposed to computationally estimate those activities and regulations. During the past decade, significant progresses have been made towards understanding pollen development at each development stage under the molecular level, yet the regulatory mechanisms that control the dynamic …
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