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The increasing awareness of customers toward climate change effects, the high demand instability affecting several industrial sectors, and the fast automation and digitalization of production systems are forcing companies to re-think their business strategies and models in view of both the Circular Economy (CE) and Industry 4.0 (I4.0) paradigms. Some studies have already assessed the relations between CE and I4.0, their benefits, and barriers. However, a practical demonstration of their potential impact in real contexts is still lacking. The aim of this paper is to present a laboratory application case showing how I4.0-based technologies can support CE practices by virtually testing a waste from electrical and electronic equipment (WEEE) disassembly plant configuration through a set of dedicated simulation tools. Our results highlight that service-oriented, event-driven processing and information models can support the integration of smart and digital solutions in current CE practices at the factory level.