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Problem Galectin‐1 can regulate immune responses upon infection and inflammation. We determined galectin‐1 expression in the chorioamniotic membranes and its changes during histological chorioamnionitis.

Method of study Chorioamniotic membranes were obtained from women with normal pregnancy (n = 5) and from patients with pre‐term pre‐labor rupture of the membranes (PPROM) with (n = 8) and without histological chorioamnionitis (n = 8). Galectin‐1 mRNA and protein were localized by in situ hybridization and immunohistochemistry. Galectin‐1 mRNA expression was also determined by quantitative reverse transcriptase polymerase chain reaction.

Results Galectin‐1 mRNA and protein were detected in the amniotic epithelium, chorioamniotic fibroblasts/myofibroblasts and macrophages, chorionic trophoblasts, and decidual stromal cells. In patients with PPROM, galectin‐1 mRNA expression …