作者
Sonia S Hassan, Roberto Romero, Beth Pineles, Adi L Tarca, Daniel Montenegro, Offer Erez, Pooja Mittal, Juan Pedro Kusanovic, Shali Mazaki-Tovi, Jimmy Espinoza, Chia-Ling Nhan-Chang, Sorin Draghici, Chong Jai Kim
发表日期
2010/1/1
期刊
American journal of obstetrics and gynecology
卷号
202
期号
1
页码范围
80. e1-80. e8
出版商
Mosby
简介
OBJECTIVE
MicroRNAs (miRNAs) are noncoding RNAs involved in posttranscriptional regulation of target genes. The objective of this study was to determine the miRNA expression profile of the human uterine cervix after spontaneous term labor (TL).
STUDY DESIGN
The miRNA expression pattern of cervical tissue was characterized using microarrays. Samples were collected at term from patients with (n = 8) and without (n = 9) TL. Moderated t tests and false discovery rate correction were applied. Results were confirmed using quantitative reverse transcriptase–polymerase chain reaction.
RESULTS
A total of 226 miRNAs were expressed in human cervical tissue. miR-223, miR-34b, and miR-34c were overexpressed in cervical tissue of patients with TL compared to those without. Quantitative reverse transcriptase-polymerase chain reaction assays confirmed these findings (miR-223 [fold change {FC} = 5.7], miR …
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SS Hassan, R Romero, B Pineles, AL Tarca… - American journal of obstetrics and gynecology, 2010