作者
Daniel Montenegro, Roberto Romero, Beth L Pineles, Adi L Tarca, Yeon Mee Kim, Sorin Draghici, Juan Pedro Kusanovic, Jung-Sun Kim, Offer Erez, Shali Mazaki-Tovi, Sonia Hassan, Jimmy Espinoza, Chong Jai Kim
发表日期
2007/9/1
期刊
American journal of obstetrics and gynecology
卷号
197
期号
3
页码范围
289. e1-289. e6
出版商
Mosby
简介
OBJECTIVE
The aim of this study was to identify differential expression of microRNAs (miRNAs) in chorioamniotic membranes with advancing gestation, labor, and inflammation.
STUDY DESIGN
Expression profiles of 157 miRNAs in the chorioamniotic membranes were obtained from patients in the following groups: 1) term not in labor (n = 10); 2) term in labor (n = 10); 3) preterm labor with histologic chorioamionitis (n = 9); and 4) without histologic chorioamnionitis (n = 10).
RESULTS
More than 95% of the miRNAs screened were expressed. Gestational age-dependent changes in expression were observed for 13 miRNAs. No differences in miRNA expression were observed between women without labor and women in labor. Membranes with chorioamnionitis displayed increased expression of miR-223 and miR-338. Gene Ontology analysis of genes targeted by differentially expressed miRNAs revealed …
学术搜索中的文章
D Montenegro, R Romero, BL Pineles, AL Tarca… - American journal of obstetrics and gynecology, 2007