作者
Ahsun Riaz, Robert K Ryu, Laura M Kulik, Mary F Mulcahy, Robert J Lewandowski, Jeet Minocha, Saad M Ibrahim, Kent T Sato, Talia Baker, Frank H Miller, Steven Newman, Reed Omary, Michael Abecassis, Al B Benson III, Riad Salem
发表日期
2009/12/1
期刊
Journal of clinical oncology
卷号
27
期号
34
页码范围
5734-5742
出版商
American Society of Clinical Oncology
简介
Purpose
Alpha-fetoprotein (AFP) is considered to be an indicator of tumor activity in hepatocellular carcinoma (HCC). We present a novel correlation of AFP response to radiologic response, time-to-progression (TTP), progression-free survival (PFS), and overall survival (OS) in patients treated with locoregional therapies.
Patients and Methods
Four hundred sixty-three patients with HCC were treated with chemoembolization or radioembolization at our institution. One hundred twenty-five patients with baseline AFP higher than 200 ng/mL were studied for this analysis. AFP response was defined as more than 50% decrease from baseline. One hundred nineteen patients with follow-up imaging were studied for the AFP imaging correlation analysis. AFP response was correlated to radiologic response, TTP, PFS, and OS. Multivariate analyses were performed.
Results
Eighty-one patients (65%) showed AFP response …
引用总数
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A Riaz, RK Ryu, LM Kulik, MF Mulcahy… - Journal of clinical oncology, 2009