作者
Amir Shamshirian, Keyvan Heydari, Zahra Shams, Amir Reza Aref, Danial Shamshirian, Omid Reza Tamtaji, Zatollah Asemi, Layla Shojaie, Hamed Mirzaei, Neda Mohammadi, Behdad Zibaee, Keyvan Karimifar, Bahman Zarandi, Akbar Hedayatizadeh-Omran, Reza Alizadeh-Navaei
发表日期
2020/12/14
来源
Hormone molecular biology and clinical investigation
卷号
41
期号
4
页码范围
20200021
出版商
De Gruyter
简介
Objectives
Breast cancer is known as one of the deadliest forms of cancer, and it is increasing globally. There are a variety of proven and controversial risk factors for this malignancy. Herein, we aimed to undertake a systematic review and meta-analysis focus on the epidemiology of breast cancer risk factors in Iran.
Methods
We performed a systematic search via PubMed, Scopus, Web of Science, and Persian databases for identifying studies published on breast cancer risk factors up to March 2019. Meta-analyses were done for risk factors reported in more than one study. We calculated odds ratios (ORs) with corresponding 95% confidence intervals (CIs) using a fixed/random-effects models.
Results
Thirty-nine studies entered into the meta-analysis. Pooling of ORs showed a significant harmful effect for risk factors including family history (OR: 1.80, 95%CI 1.47–2.12), hormonal replacement therapy (HRT) (OR: 5.48 …
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A Shamshirian, K Heydari, Z Shams, AR Aref… - Hormone molecular biology and clinical investigation, 2020