作者
SH Mohammadi, M Gholamin, M Mohammadi, A Mansouri, R Mahmoodian, S Attari, SM Kebriaei, B Zibaei, M Roshanaei, F Daneshvar, M Khandehro, MA Khodadadegan, A Delshad, F Mohammadzadeh, Mostafa Peyvandi, Majid Ghayour-Mobarhan, Shima Tavallaie, Samaneh Boroumand-Noughabi, Gordon AA Ferns
发表日期
2018/4/1
期刊
Environmental Toxicology and Pharmacology
卷号
59
页码范围
82-86
出版商
Elsevier
简介
In the study of the expression of CatSper genes, consideration of the effects of environmental metal toxicity is very important. Therefore, in this study, the effects of lead acetate and mercury chloride exposure on expression of CatSper genes, sperm parameters, histology of testis and prooxidant antioxidant balance (PAB) values of serum were investigated.
A total of 28 mice was divided into four groups. The control group did not receive injections. The sham group received normal saline intraperitoneally. Lead and mercury groups were injected 60 and 1.25 mg/kg/daily lead acetate and mercury chloride respectively intraperitoneally for 2 weeks. After 35 days, the sperm analysis and histology of left testis were performed. In addition, serum was obtained to measure the PAB values. The right testis was used for molecular analysis of real-time PCR.
Administration with either lead acetate or mercury caused significant …
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SH Mohammadi, M Gholamin, M Mohammadi… - Environmental Toxicology and Pharmacology, 2018