作者
Natalia Manzano-León, Jesús Serrano-Lomelin, Brisa N Sánchez, Raúl Quintana-Belmares, Elizabeth Vega, Inés Vázquez-López, Leonora Rojas-Bracho, Maria Tania López-Villegas, Felipe Vadillo-Ortega, Andrea De Vizcaya-Ruiz, Irma Rosas Perez, Marie S O’Neill, Alvaro R Osornio-Vargas
发表日期
2016/4
期刊
Environmental health perspectives
卷号
124
期号
4
页码范围
406-412
出版商
National Institute of Environmental Health Sciences
简介
Background
Observed seasonal differences in particulate matter (PM) associations with human health may be due to their composition and to toxicity-related seasonal interactions.
Objectives
We assessed seasonality in PM composition and in vitro PM pro-inflammatory potential using multiple PM samples.
Methods
We collected 90 weekly PM10 and PM2.5 samples during the rainy-warm and dry-cold seasons in five urban areas with different pollution sources. The elements, polycyclic aromatic hydrocarbons (PAHs), and endotoxins identified in the samples were subjected to principal component analysis (PCA). We tested the potential of the PM to induce tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6) secretion in cultured human monocytes (THP-1), and we modeled pro-inflammatory responses using the component scores.
Results
PM composition varied by size and by season. PCA identified two main …
学术搜索中的文章
N Manzano-León, J Serrano-Lomelin, BN Sánchez… - Environmental health perspectives, 2016