作者
Reza Ghotaslou, Hamed Ebrahimzadeh Leylabadlo, Mohammad Javad Nasiri, Hossein Dabiri, Ali Hashemi
发表日期
2018/5/1
来源
Microbial pathogenesis
卷号
118
页码范围
214-219
出版商
Academic Press
简介
Introduction
It has been proposed that specific analysis of Helicobacter pylori virulence factors can be suitable for predicting of post H. pylori infection disorders like gastric cancer (GC). The present study was designed to evaluate the association between different virulence factors of H. pylori and GC.
Methods
Studies investigated the association between virulence factors of H. pylori and GC were collected from the several databases. All analysis was performed by Comprehensive Meta-Analysis V2.2 software (Biostat, Englewood, NJ, USA).
Results
Based on a comprehensive literature search, 25 eligible studies were included for meta-analyses. Infection with cagA- and vacA s1m1-positive H. pylori strains were significantly associated with increased risk of GC (OR of [2.82 (95% CI 1.96–4.06), P < 0.001]) and ([1.75 (95% CI 1.04–2.96), P 0.034)], respectively.
Conclusions
Infection by H. pylori strains with positive vacA …
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