作者
Ole Köhler-Forsberg, Henriette N Buttenschøn, Katherine E Tansey, Wolfgang Maier, Joanna Hauser, Mojca Zvezdana Dernovsek, Neven Henigsberg, Daniel Souery, Anne Farmer, Marcella Rietschel, Peter McGuffin, Katherine J Aitchison, Rudolf Uher, Ole Mors
发表日期
2017/5/1
期刊
Brain, behavior, and immunity
卷号
62
页码范围
344-350
出版商
Academic Press
简介
Introduction
Population-based studies have associated inflammation, particularly higher C-reactive protein (CRP), with depressive severity, but clinical trials in major depressive disorder were rather non-specific without examining the role of gender. We aimed to investigate the association between CRP and overall depression severity including specific depressive symptoms and to examine potential gender differences.
Methods
We included 231 individuals with major depressive disorder from the Genome-Based Therapeutics Drugs for Depression (GENDEP) study. At baseline, we assessed high-sensitivity CRP levels and psychopathology with the Montgomery Aasberg Depression Rating Scale (MADRS). We performed linear regression analyses to investigate the association between baseline CRP levels with overall MADRS severity and specific symptoms at baseline and adjusted for age, gender, anti …
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O Köhler-Forsberg, HN Buttenschøn, KE Tansey… - Brain, behavior, and immunity, 2017