作者
Carlos King Ho Wong, Lung Yi Mak, Ivan Chi Ho Au, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Celine Sze Ling Chui, Esther Wai Yin Chan, Wing Yiu Cheng, Franco Wing Tak Cheng, Man Fung Yuen, Ian Chi Kei Wong
发表日期
2022/11/1
期刊
Journal of hepatology
卷号
77
期号
5
页码范围
1339-1348
出版商
Elsevier
简介
Background & Aims
Case reports of severe acute liver injury (ALI) following COVID-19 vaccination have recently been published. We evaluated the risks of ALI following COVID-19 vaccination (BNT162b2 or CoronaVac).
Methods
We conducted a modified self-controlled case series analysis using the vaccination records in Hong Kong with data linkage to electronic medical records from a territory-wide healthcare database. Incidence rate ratios (IRRs) for ALI outcome in the 56-day period following first and second doses of COVID-19 vaccines in comparison to the non-exposure period were estimated and compared to the ALI risk in patients with SARS-CoV-2 infection.
Results
Among 2,343,288 COVID-19 vaccine recipients who were at risk, 4,677 patients developed ALI for the first time between 23rd February 2021 to 30th September 2021. The number of ALI cases within 56 days after the first and second dose of …
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CKH Wong, LY Mak, ICH Au, FTT Lai, X Li, EYF Wan… - Journal of hepatology, 2022