作者
Nicola Low, Anne McCarthy, John Macleod, Chris Salisbury, Rona Campbell, Tracy E Roberts, Paddy Horner, Susan Skidmore, JA Sterne, Emma Sanford, Fowzia Ibrahim, Aisha Holloway, Rita Patel, Pelham M Barton, Suzanne M Robinson, Nicholas Mills, Anna Graham, Alan Herring, E Owen Caul, FD Hobbs, JD Ross, M Egger
发表日期
2007/3/1
来源
Health technology assessment (Winchester, England)
卷号
11
期号
8
页码范围
iii-iv, ix
简介
Objectives
To investigate epidemiological, social, diagnostic and economic aspects of chlamydia screening in non-genitourinary medicine settings.
Methods
Linked studies around a cross-sectional population-based survey of adult men and women invited to collect urine and (for women) vulvovaginal swab specimens at home and mail these to a laboratory for testing for Chlamydia trachomatis. Specimens were used in laboratory evaluations of an amplified enzyme immunoassay (PCE EIA) and two nucleic acid amplification tests [Cobas polymerase chain reaction (PCR), Becton Dickinson strand displacement amplification (SDA)]. Chlamydia-positive cases and two negative controls completed a risk factor questionnaire. Chlamydia-positive cases were invited into a randomised controlled trial of partner notification strategies. Samples of individuals testing negative completed psychological questionnaires before and after screening. In-depth interviews were conducted at all stages of screening. Chlamydia transmission and cost-effectiveness of screening were investigated in a transmission dynamic model.
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N Low, A McCarthy, J Macleod, C Salisbury… - Health technology assessment (Winchester, England), 2007