作者
Laurence Klotz, Joseph Chin, Peter C Black, Antonio Finelli, Maurice Anidjar, Ashley Machado, Mark Levental, Sangeet Ghai, Silvia D Chang, Chirag Patel, Zahra Kassam, Andrew Loblaw, Marlene Kebabdjian, Greg Pond, Masoom A Haider
发表日期
2024/6/1
期刊
European Urology Oncology
卷号
7
期号
3
页码范围
456-461
出版商
Elsevier
简介
Background
The prospective randomized PRECISE trial demonstrated that magnetic resonance imaging (MRI) with only targeted biopsy (TBx) was noninferior to systematic transrectal ultrasound biopsy (SBx) in the detection of International Society of Urological Pathology grade group (GG) ≥2 prostate cancer (PC). An unanswered question is the outcome for patients who avoided a biopsy because of negative MRI findings.
Objective
To explore the rate of PC diagnosis based on 2-yr MRI for PRECISE participants who had no biopsy and for patients who had a negative result or GG 1 on TBx in comparison to those with a negative result or GG 1 on SBx.
Design, setting, and participants
The PRECISE prospective trial was conducted at five Canadian academic centers. The present analysis was for trial participants who were not diagnosed with clinically significant PC (csPC) at baseline. Of 453 randomized patients, 146 …
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L Klotz, J Chin, PC Black, A Finelli, M Anidjar… - European Urology Oncology, 2024