作者
Graham A Wilson, Kirsten Cheyne, Sandhya Ramrakha, Antony Ambler, Gavin SW Tan, Avshalom Caspi, Ben Williams, Karen Sugden, Renate Houts, Rachael L Niederer, Tien Yin Wong, Terrie E Moffitt, Richie Poulton
发表日期
2023/1/2
期刊
Clinical and Experimental Optometry
卷号
106
期号
1
页码范围
41-46
出版商
Taylor & Francis
简介
Clinical relevance
Macular drusen are associated with age-related maculopathy but are not an ocular manifestation or biomarker of systemic ageing.
Background
Macular drusen are the first sign of age-related maculopathy, an eye disease for which age is the strongest risk factor. The aim of this cohort study was to investigate whether macular drusen in midlife – a sign of the earliest stages of age-related macular degeneration (AMD) – are associated with accelerated biological ageing more generally.
Methods
Members of the long-running Dunedin Multidisciplinary Health and Development Study (hereafter the Dunedin Study, n = 1037) underwent retinal photography at their most recent assessment at the age of 45 years. Images were graded for the presence of AMD using a simplified scale from the Age-Related Eye Disease Study (AREDS). Accelerated ageing was assessed by (i) a measure of Pace of Ageing …
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GA Wilson, K Cheyne, S Ramrakha, A Ambler… - Clinical and Experimental Optometry, 2023