作者
Guilherme Polanczyk, Avshalom Caspi, Benjamin Williams, Thomas S Price, Andrea Danese, Karen Sugden, Rudolf Uher, Richie Poulton, Terrie E Moffitt
发表日期
2009/9/1
期刊
Archives of general psychiatry
卷号
66
期号
9
页码范围
978-985
出版商
American Medical Association
简介
Context
A previous study reported a gene × environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1)was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]).
Objective
To replicate the interaction between childhood maltreatment and a TAT haplotype formed by rs7209436, rs110402, and rs242924 inCRHR1, predicting adult depression.
Design
Two prospective longitudinal cohort studies.
Setting
England and New Zealand.
Participants
Participants in the first sample were women in the E-Risk Study (N = 1116), followed up to age 40 years with 96% retention. Participants in the second sample were men and women in the Dunedin Study (N = 1037), followed up to age 32 years with 96% retention.
Main Outcome Measure
Research diagnoses of past …
引用总数
学术搜索中的文章
G Polanczyk, A Caspi, B Williams, TS Price, A Danese… - Archives of general psychiatry, 2009