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CD8⁺ T cells play an essential role against tumors but the role of human CD8⁺CD26⁺ T cell subset against tumors, in particular, haematological cancers such as chronic lymphocytic leukemia (CLL) remains unknown. Although CD4⁺CD26^high T cells are considered for adoptive cancer immunotherapy, the role of CD8⁺CD26⁺ T cells is ill-defined. Therefore, further studies are required to better determine the role of CD8⁺CD26⁺ T cells in solid tumors and haematological cancers.

We studied 55 CLL and 44 age-sex-matched healthy controls (HCs). The expression of CD26 on different T cell subsets (e.g. naïve, memory, effector, and etc.) was analyzed. Also, functional properties of CD8⁺CD26⁺ and CD8⁺CD26⁻ T cells were evaluated. Finally, the plasma cytokine/chemokine and Galectin-9 (Gal-9) levels were examined.

CD26 expression identifies three CD8⁺ T cell subsets with distinct …